The Nobel Prize in medicine was awarded this morning to researchers whose work provided key insights into how the immune system is activated.
Three researchers, Bruce A. Beutler of the United States, Jules A. Hoffmann, born in Luxembourg, and the late Dr. Ralph M. Steinman, of Canada, won the prize of $1.5 million (10 million kronor). Steinman was awarded half the prize and Beutler and Hoffmann shared the other half.
Beutler and Hoffmann discovered proteins on the surface of immune cells (receptors) that recognize microorganisms and activate innate immunity — the body's first line of defense against potentially harmful pathogens. Beutler identified the role of so-called Toll receptors in 1996, and Hoffmann identified Toll-like receptors in 1998.
In 1973, Steinman discovered cells of the immune system called dendritic cells. These cells activate part of the adaptive immune system response – a later stage of the immune response during which microorganisms are cleared from the body.
“The discoveries of the three Nobel Laureates have revealed how the innate and adaptive phases of the immune response are activated and thereby provided novel insights into disease mechanisms,” the Nobel committee said in a statement. “Their work has opened up new avenues for the development of prevention and therapy against infections, cancer, and inflammatory diseases.”
Their findings help improve vaccines against infections, the committee said. They also helped us understand why the body's immune system can attack it's own tissues, as is the case in autoimmune diseases.
Beutler is a currently researcher in the genetics department at The Scripps Research Institute, La Jolla, Calif. Hoffman headed a research laboratory in Strasbourg, France, from 1974 to 2009, and was president of the French National Academy of Sciences between 2007 and 2008.
Rockefeller University says Nobel medicine prize winner Ralph Steinman died on Sept. 30. Steinman was a senior physician and head of a cellular physiology and immunology laboratory at that university in New York City, according to the university's website.
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Editor's note: This story has been updated from an earlier version, which did not include the information about Steinman's death.
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